Gene nominations

Every gene reachable from a risk locus in two colocalization steps: the GWAS signal shares a causal variant with a CpG’s methylation signal (GWAS↔CpG), and the same methylation signal shares a causal variant with the gene’s expression in independent data (CpG↔gene). The chain score is the weaker of the two links, so a chain is only as strong as its weakest step.

High tier means both links reach 0.8, the same threshold used for direct colocalization elsewhere on the site; suggestive means the weaker link falls between 0.5 and 0.8. The orphan column flags loci where no expression test of any kind succeeded, which is where these chains matter most. The direct eQTL PP4 column shows what direct testing said about this gene, and the CpG–TSS column gives the distance from the methylation site to the gene’s start; the checkbox filter keeps chains within 100 kb.